Tranexamic Acid + Mesotherapy: The Secret to a Brighter, Even Skin Tone

If you’ve been struggling with stubborn pigmentation like melasma, post-inflammatory hyperpigmentation (PIH), or even rosacea, you’re not alone. These skin concerns can be persistent and difficult to treat. Fortunately, tranexamic acid (TXA) has emerged as a powerful solution in the skincare world. Whether used in topical skincare or mesotherapy treatments, TXA is proving to be a game-changer in achieving a more even, radiant complexion.

What Is Tranexamic Acid?

Tranexamic acid (TXA) was originally used in medicine for its blood-clotting properties. However, researchers later discovered its impressive ability to reduce pigmentation and brighten skin tone, leading to its use in dermatology. In 2005, both China Taiwan and Japan’s health authorities officially recognized TXA as an effective whitening agent.

How Does Tranexamic Acid Work for Skin?

Unlike other brightening agents like vitamin C and niacinamide, which target only specific stages of melanin production, Tranexamic Acid works at multiple levels:

√ Inhibits melanin production at the early stages

√ Prevents melanin transfer and clustering, stopping dark spots from spreading

√ Reduces inflammation, a key factor in melasma and PIH

√ Strengthens the skin barrier, improving resilience against external damage

Tranexamic Acid also blocks the release of prostaglandin E2 (PGE2) and proteinase-activated receptor-2 (PAR-2)—two major players in pigmentation formation. This makes TXA not only an effective skin-brightening ingredient but also a great option for sensitive skin prone to redness and inflammation.

Mesotherapy with Tranexamic Acid: A Targeted Solution

One of the most effective ways to deliver TXA deep into the skin is through mesotherapy—a treatment that involves micro-application of active ingredients directly into the skin’s dermis.

Take PLLA Nutrients Fills as an example. This innovative formula contains tranexamic acid along with a blend of skin-rejuvenating nutrients. When applied via mesotherapy, it helps to:

- Break up stubborn pigmentation and even out skin tone

- Reduce inflammation and redness, making it ideal for melasma and rosacea

- Boost collagen production, improving skin texture and elasticity

Case Study: Brightening & Even-Toned Skin with Tranexamic Acid Mesotherapy

A  46 years old patient has melasma with recurrent facial rash for nearly 10 years underwent three sessions of mesotherapy with PLLA Nutrients Fills (containing TXA) in three months. After three months, her skin showed:

1. MASI score from 14.4 before treatment to 3.6 after treatment.

2. A significant reduction in dark patches and an overall brighter complexion

3. Less redness and inflammation, leading to smoother, more even-toned skin

4. Improved skin hydration and firmness, thanks to the added nutrients in the formula

Unlike traditional topical creams, mesotherapy allows PLLA Nutrients Fills with Tranexamic Acid to penetrate deeper, making it a more targeted and effective solution for hyperpigmentation.

Tranexamic acid is a powerful yet gentle option for tackling melasma, PIH, and rosacea. Whether used in topical skincare or advanced treatments like mesotherapy with PLLA Nutrients Fills, it can help brighten your skin and restore a healthy, even tone.