Understanding Melasma: Causes, Treatments, and How PLLA Nutrients Fills Can Help

January 10, 2025
By ZQ-II®


Melasma is a common skin condition characterized by dark pigmented spots on the face that can be an ongoing challenge for many people. Melasma typically appears on the cheeks, forehead, upper lip, and chin and is more common in women, especially during pregnancy or when using hormonal birth control pills. Below the causes of melasma, available treatments, and how PLLA Nutrients Fills works will be explored.

Causes of Melasma

1. Sun exposure:

Excessive sun exposure is one of the main causes of melasma. The sun’s ultraviolet rays, especially UVA and UVB, stimulate melanocytes (pigment-producing cells) to overproduce melanin, causing dark spots to appear on the skin. Prolonged exposure to the sun can worsen melasma, making it more difficult to treat.

2. Hormonal imbalances:

Hormonal fluctuations, especially those associated with pregnancy, the use of oral contraceptives, or hormone replacement therapy can all trigger or worsen melasma. Changes in hormone levels can affect melanin production, causing pigment spots to form on the face.

3. Genetic factors:

Some people are genetically predisposed to melasma. If your parents or close relatives have had melasma, you are more likely to develop it, too.

4. Damaged skin barrier:

A weakened skin barrier can worsen melasma. Factors such as excessive sun exposure, harsh skincare products, or environmental pollutants can damage the outer layer of the skin and trigger pigmentation. Once the skin barrier is damaged, melanocytes become more active and produce excess melanin.

5. Inflammation:

Inflammation of the skin, whether from acne, chemical irritation, or poorly formulated skincare products, can contribute to the formation of melasma. The inflammatory response triggers melanocyte activity, causing further darkening of the skin.

Effective treatments for melasma

1.Q-switched laser: Utilizes 1064nm Nd:YAG lasers to selectively target melanin, breaking down pigment particles without damaging surrounding tissue, effectively reducing melasma.

2.Picosecond laser: Provides faster and more precise treatments, breaking down melanin into microparticles for natural metabolism, with a lower risk of pigment rebound.

3.Chemical peels: contain glycolic acid or trichloroacetic acid, which remove the outer layer of the skin, promote cell renewal, and improve superficial melasma and skin texture.

4.Non-ablative fractional lasers: such as 1540nm and 1550nm wavelengths, stimulate collagen production and target mild to moderate melasma without damaging the skin surface.

5.Mesotherapy and microneedling: Mesotherapy involves applying active ingredients like vitamin C or tranexamic acid directly into the skin to reduce pigmentation. PLLA Nutrients Fills in microneedling way, on the other hand, creates tiny channels in the skin to absorb active ingredients, stimulating collagen production while treating pigmentation issues.

How PLLA Nutrients Fills Helps Treat Melasma

PLLA (Poly-L-Lactic Acid) is a biocompatible substance used in aesthetic medicine, especially for skin rejuvenation. While PLLA is traditionally used for facial volume restoration and collagen stimulation, PLLA Nutrients Fills has also shown excellent results in treating melasma.

PLLA Nutrients Fills works through a unique mechanism, releasing lactic acid into the skin. This lactic acid plays a vital role in inhibiting the activity of tyrosinase, an enzyme directly involved in melanin production. By reducing melanin synthesis, PLLA effectively brightens the skin, making it an ideal choice for addressing pigmentation issues such as melasma.

A patient with stubborn melasma underwent a course of PLLA Nutrients Fills treatments. After just a few treatments, the skin looked more even-toned and pigmentation was noticeably reduced. The patient reported that the skin felt firmer and dark spots faded noticeably over time. PLLA Nutrients Fills works by promoting healthier skin structure, which not only reduces the appearance of melasma but also helps prevent its recurrence.

Melasma is characterized by dark, patchy discoloration on the skin that often requires targeted treatment. PLLA Nutrients Fills not only helps to lighten these areas of pigmentation, but also promotes skin rejuvenation and improves overall appearance. With its dual action of inhibiting pigmentation and improving skin texture, improving skin health from within, it is a versatile and effective option for those seeking a brighter, more even complexion and has become a valuable tool in the fight against stubborn pigmentation issues like melasma.


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